Ernest Hemingway, one of America’s greatest writers, died from hereditary hemochromatosis on July 2, 1961, exactly 50 years ago today. He was one of many Hemingways who succumbed to America’s most prevalent genetic killer.
You might have read that Hemingway died of a self-inflicted gunshot wound, but hereditary hemochromatosis–also known as HHC, iron overload, bronze diabetes and Celtic Curse–was undoubtedly the underlying cause of his death. Depression and suicide are closely associated with hemochromatosis, as is the diabetes that afflicted Hemingway, along with his liver problems and high blood pressure.
Quite by coincidence, July is Hemochromatosis Awareness Month in America, a time to raise awareness of what we now know is the most common genetic killer in America. By raising awareness of HHC you can quite literally save lives. And if a giant of literature can help raise HHC awareness, so be it.
How did hemochromatosis kill Hemingway? By causing toxic levels of iron to accumulate in his joints and organs bringing pain, diabetes, cirrhosis of the liver, heart disease, and depression. That depression is more than just being unhappy because your body is damaged and your health is failing. That toxic iron accumulation plays its own role in affecting mood and brain function. Sadly, suicide is an all-too-common outcome of undiagnosed hemochromatosis.
Back in the 1950s, when Ernest Hemingway’s health really started to deteriorate, doctors did not have direct evidence that hemochromatosis was genetic, although some doctors were sure that it was an inherited condition. The genetic connection was made in 1996 through research on the HFE gene. This discovery led to a genetic test for the condition and doctors quickly discovered that HHC was a much more common condition than previously thought.
How common is inherited hemochromatosis? Calculations based on field research vary but 1 in 200 Americans is probably a good estimate. Very few potentially fatal genetic conditions, if any, come close to that level of occurrence. Historically the frequency of HHC is higher in populations with an Irish or Celtic connection (the condition is referred to as hereditary hemochromatosis in America, but in Ireland, Scotland, and other parts of Europe, the condition is called genetic haemochromatosis).
Of course, after President Obama’s recent visit with relatives in Ireland, it would be a mistake to characterize HHC as a white or Caucasian or Northern European condition. You can have HHC in your genes pretty much regardless of your physical appearance.
Sadly, the Hemingway family history is a classic saga of HHC. Ernest Hemingway’s father Clarence committed suicide, as had his father before him. Ernest Hemingway’s sister Ursula, and his brother Leicester, also committed suicide. The father of Hemingway’s first wife, Hadley, committed suicide. From what we now know of genetics and hemochromatosis, all of them would have had hereditary hemochromatosis. Gregory Hemingway, later Gloria Hemingway, died a classic hemochromatosis death from hypertension and cardiovascular disease.
Fortunately, it doesn’t have to be this way. Hemochromatosis can be treated and its effects limited and controlled. Treatment of HHC is not only FREE but HHC gives back to society in a way no other disease does! That’s because the treatment for excess iron is to take blood (that is, give blood from the perspective of the hemochromatosis patient being treated).
As for detection and diagnosis, a genetic test that can reveal your HFE gene status is available for less than $100 (a good example is the 23andme service). And simple blood tests that can detect elevated iron levels cost just a few dollars. If you have any reason to think you might have HHC you should ask your doctor to order these tests.
Acceptable reasons include any of the symptoms of HHC and/or a family history of liver disease, depression, suicide, joint pain, or diabetes. (And don’t let anyone tell you that cirrhosis of the liver is always caused by alcohol so your relatives with liver problems are/were heavy drinkers; this story reported in the Washington Post proves otherwise.)
Ernest Hemingway was a giant of American arts and letters. The Winner of a Pulitzer for his fiction, he is one of just five Americans who were among the first 50 winners of the Nobel Prize in Literature. His life and writings continue to inspire and inform people around the world. Now, in the story of his death, his legacy can include saving lives by spreading the word of this treatable but widely under-diagnosed condition, hereditary hemochromatosis.